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81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Prof. Haass started to work on Alzheimer's disease (AD) rein 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion hinein this field that Aß may be produced from its precursor rein a physiologically häufig pathway and not necessarily hinein a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding was a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved hinein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production in patients.
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Together with an interdiziplinary team he uncovered the molecular mechanisms of Alzheimer's disease and identified target molecules for therapeutic treatment.
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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass was the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which was overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He welches also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved hinein brain development (such as myelination and cell differentiation) but also provided the Lager for several current therapeutic approaches.
einer elektrischen Antriebsmaschine oder einem Verbrennungsmotor mit einem Hubraum von nicht mehr denn 50 zentimeter³ oder
Haass welches awarded the Hector Science Award and is currently leading a major project on the clinical testing of an Alzheimer's antibody.
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Leichte zweirädrige Kraftfahrzeuge mit einer durch die Bauart bestimmten Höchstgeschwindigkeit von nicht mehr wie 45 kilometer pro stunde, einer Nenndauerleistung/Nutzleistung von nicht etliche denn 4 kW ebenso einem Verbrennungsmotor mit einem Hubraum von nicht eine größere anzahl als 50 cm³ oder einer anderen Antriebsform.
We work on the molecular and cellular mechanisms of neurodegeneration with a strong focus on Alzheimer’s disease and related disorders. We are searching for therapeutic targets within the amyloid cascade. Secretases, amyloid metabolism and microglial function are within the focus of our research.